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Journal of Thoracic Oncology : Official... Dec 2008
Topics: Carcinoma, Bronchogenic; Female; Humans; Lung Neoplasms; Lung Transplantation; Male; Radiography
PubMed: 19057259
DOI: 10.1097/JTO.0b013e318190b2c0 -
Medical Science Monitor : International... Apr 2019BACKGROUND The present study aimed to evaluate the difference in microbiota diversity in the oral cavity and fluid bronchoalveolar lavage (BALF) of patients with lung...
BACKGROUND The present study aimed to evaluate the difference in microbiota diversity in the oral cavity and fluid bronchoalveolar lavage (BALF) of patients with lung cancer. MATERIAL AND METHODS Buccal (saliva) and lower respiratory tract BALF samples were collected from 51 patients with primary bronchogenic carcinoma and 15 healthy controls, and bacterial genomic DNA was extracted. High-throughput 16S rDNA amplicon sequencing was performed, and microbial diversity, composition, and functions of microbiota were analyzed by bioinformatics methods. RESULTS Patients with lung cancer have lower microbial diversity than healthy controls in both saliva and BALF samples. Significant segregation was observed between the different pathological types of lung cancer groups and the control group regardless of the sampling site. Treponema and Filifactor were identified as potential bacterial biomarkers in BALF samples, while Filifactor was ideal to distinguish healthy controls from lung cancer patients. Moreover, the predictive variation analysis of the KEGG (Kyoto Encyclopedia of Genes and Genomes) metabolic pathway showed that the metabolic differences in microbiota varied by sampling site. CONCLUSIONS Lung cancer patients carry a different and less diverse microorganism community than healthy controls. Certain bacterial taxa might be associated with lung cancer, but the exact species depends on the sampling site and the pathological type. This study provides basic data on the microbiota diversity in BALF and saliva samples from lung cancer patients. Further investigation with a larger sample size should help validate the enriched species in different pathological types of lung cancers.
Topics: Adult; Aged; Bacteria; Biomarkers, Tumor; Bronchoalveolar Lavage; Bronchoalveolar Lavage Fluid; Carcinoma, Bronchogenic; Female; Humans; Lung Neoplasms; Male; Microbiota; Middle Aged; Preliminary Data; Saliva
PubMed: 30994108
DOI: 10.12659/MSM.915332 -
British Journal of Cancer Jun 1963
Topics: Bronchial Neoplasms; Carcinoma; Carcinoma, Bronchogenic; Humans; Lung Diseases; Radiography, Thoracic; Sarcoidosis
PubMed: 14042719
DOI: 10.1038/bjc.1963.29 -
Zhongguo Fei Ai Za Zhi = Chinese... Jan 2011Lung transplantation is an efficient therapeutic option for patients with end-stage pulmonary diseases, but less is known about lung cancer after lung transplantation.... (Review)
Review
BACKGROUND AND OBJECTIVE
Lung transplantation is an efficient therapeutic option for patients with end-stage pulmonary diseases, but less is known about lung cancer after lung transplantation. The aim of this study is to improve the awareness, diagnosis and treatment of bronchogenic carcinoma after lung transplantation with a case report and related literatures.
METHODS
We reported a 65-year-old male with idiopathic pulmonary fibrosis (IPF) who underwent right lung transplantation under extracorporeal membrane oxygenation (ECMO) support in May 2007 in our hospital. The patient recovered smoothly and discharged from the hospital 46 days after the procedure with regular follow-up. Immunosuppression therapy was triple drug maintenance regimen including tacrolimus (Tac), mycophenolate mofetil (MMF) and steroids.
RESULTS
Small cell lung cancer in the left lung with multiple osseous metastases was found 13 months after the lung transplantation. Symptoms were relieved a bit by administering chemotherapeutics (etoposide and cisplatin) for 4 cycles. However, the patient was succumbed to his illness within 11 months after the diagnosis of lung cancer.
CONCLUSIONS
Lung cancer after lung transplantation has been suggested as one of causes of late mortality with the risk factors such as chronic obstructive pulmonary disease (COPD), IPF, cigarette smoking history and immunosuppression etc. Early diagnosis and treatment are very important to improve the prognosis.
Topics: Aged; Antineoplastic Agents; Carcinoma, Bronchogenic; Fatal Outcome; Humans; Idiopathic Pulmonary Fibrosis; Lung Neoplasms; Lung Transplantation; Male
PubMed: 21219838
DOI: 10.3779/j.issn.1009-3419.2011.01.16 -
Cancer Aug 2008More cases of bronchogenic carcinoma have been reported in recent years, and these patients are more prone to secondary aspergillosis. However, the frequency of... (Comparative Study)
Comparative Study
Bronchogenic carcinoma and secondary aspergillosis--common yet unexplored: evaluation of the role of bronchoalveolar lavage-polymerase chain reaction and some nonvalidated serologic methods to establish early diagnosis.
BACKGROUND
More cases of bronchogenic carcinoma have been reported in recent years, and these patients are more prone to secondary aspergillosis. However, the frequency of secondary aspergillosis in bronchogenic carcinoma still has not been defined clearly in the literature.
METHODS
The current study population was comprised of 69 patients with bronchogenic carcinoma and 16 healthy controls. Histopathologic examination was done to identify carcinoma cell types and to categorize aspergillosis types. Bronchoalveolar lavage (BAL) fluids were collected for direct fungal examination, culture, Aspergillus polymerase chain reaction (PCR), and galactomannan (GM) detection using a 1-stage immunoenzymatic sandwich microplate assay; and blood samples were collected for fungal serology by double immunodiffusion (DID), enzyme-linked immunosorbent assay (ELISA), and dot blot assay (DBA). The sensitivity, specificity, positive predictive value, and negative predictive value were analyzed for various nonvalidated tests. Twenty-five patients had follow-up data available for an analysis of clinical and diagnostic outcomes.
RESULTS
The cohort included patients with squamous cell carcinoma (n = 47), adenocarcinoma (n = 16), small cell carcinoma (n = 3), large cell carcinoma (n = 2), and undiagnosed type (n = 1), and patients were categorized with definite invasive pulmonary aspergillosis (IPA) (n = 6), probable IPA (n = 17), possible IPA (n = 13), and non-IPA (n = 33). Most patients were in the group ages 45 years to <60 years, and there was a preponderance of men (10.5:1). Cultures from 20 of 69 patients (29%) revealed the growth of Aspergillus species. Anti-Aspergillus antibodies were detected in 26 of 69 patients (37.7%) each by DID and DBA, whereas antibodies were detected in 28 of 69 patients (40.6%) by ELISA. GM was detected in BAL fluids from 25 of 69 patients (36.2%), whereas Aspergillus DNA was detected in 32 of 69 patients (46.4%) by PCR. The sensitivity of PCR and serologic tests (ELISA, DID, and DBA) was 100% for definite IPA, whereas the sensitivity of PCR was comparatively higher than that of serologic tests for probable IPA, possible IPA, and non-IPA.
CONCLUSIONS
The current study indicated that there frequently is an association between bronchogenic carcinoma and secondary aspergillosis, and definite IPA and probable IPA are common clinical problems in patients with nonsmall cell lung cancer.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Algorithms; Aspergillosis; Aspergillus fumigatus; Bronchoalveolar Lavage Fluid; Carcinoma, Bronchogenic; Case-Control Studies; Cells, Cultured; Early Diagnosis; Female; Humans; Lung Diseases, Fungal; Lung Neoplasms; Male; Microbial Sensitivity Tests; Middle Aged; Polymerase Chain Reaction; Serologic Tests; Validation Studies as Topic
PubMed: 18521930
DOI: 10.1002/cncr.23570 -
BMJ (Clinical Research Ed.) Oct 1992To investigate the association between bird keeping and risk of lung cancer.
OBJECTIVE
To investigate the association between bird keeping and risk of lung cancer.
DESIGN
Case-control study asking detailed questions on exposure to domestic birds and other pets, smoking, and various demographic and potentially confounding variables.
SETTING
District general hospital; current admissions interviewed in hospital or recent admissions interviewed at home.
PATIENTS
143 patients with lung cancer, 143 controls with heart disease, and 143 controls with orthopaedic conditions individually matched for age, sex, date of admission, and current or past admission.
MAIN OUTCOME MEASURES
Odds ratios for lung cancer in relation to various aspects of bird keeping, after adjustment for smoking and other relevant confounding variables.
RESULTS
Risk of lung cancer was not significantly associated with household exposure to pet birds at any time or at various specific periods in life, or to keeping large numbers of birds. For specific types of birds no association was seen for living in households with budgerigars or canaries but risk was significantly associated with keeping pigeons (odds ratio 3.53, 95% confidence interval 1.56 to 7.98). This remained significant after regression analysis to account for confounding variables (3.9, 1.2 to 12.62) in both sexes and all age groups.
CONCLUSION
Bird keeping may confer some risk of lung cancer but the relation is not as strong as previously reported.
Topics: Adult; Aged; Aged, 80 and over; Animals; Animals, Domestic; Birds; Carcinoma, Bronchogenic; Case-Control Studies; Confounding Factors, Epidemiologic; Environmental Exposure; Humans; Lung Neoplasms; Male; Middle Aged; Odds Ratio; Risk Factors; Scotland; Smoking
PubMed: 1458146
DOI: 10.1136/bmj.305.6860.989 -
British Medical Journal Jul 1948
Topics: Bronchi; Carcinoma, Bronchogenic; Neoplasms
PubMed: 18871671
DOI: No ID Found -
British Medical Journal Oct 1948
Topics: Bronchi; Carcinoma, Bronchogenic; Neoplasms
PubMed: 18890295
DOI: 10.1136/bmj.2.4581.737 -
Bristol Medico-chirurgical Journal... 1948
Topics: Bronchi; Carcinoma, Bronchogenic; Neoplasms
PubMed: 18103290
DOI: No ID Found -
Asian Journal of Surgery Jul 2004Bronchoplastic and pulmonary arterioplastic procedures have become increasingly popular in recent years as an alternative to pneumonectomy, especially for patients with...
OBJECTIVES
Bronchoplastic and pulmonary arterioplastic procedures have become increasingly popular in recent years as an alternative to pneumonectomy, especially for patients with compromised cardiopulmonary reserve. We reviewed our experience with the procedure to determine the operative technique, indication for the procedure and long-term results.
METHODS
From January 1981 to December 2000, 65 bronchoplasties, four pulmonary arterioplasties and three combined broncho-angioplasties were performed for bronchogenic carcinoma.
RESULTS
Of the 72 patients, 31 had stage I disease, 29 had stage II and 12 had stage III disease. One patient (1.4%) died of bilateral pneumonitis postoperatively. Atelectasis occurred in two patients (2.8%), empyema in one (1.4%), and bronchial fistula in one (1.4%). There were no bronchial stenoses after bronchoplastic procedures, and no vascular complications after angioplastic procedures. The 1-, 3- and 5-year survival rates for the entire group were 86.0%, 47.0% and 29.8%, respectively. The difference in survival was significant between stage I and II disease (p=0.0001) and between stage I and III disease (p<0.0001), but not between stage II and III disease (p=0.0779).
CONCLUSIONS
Bronchoplastic, pulmonary arterioplastic and broncho-angioplastic procedures can be performed safely. Bronchoplastic procedures offer patients with bronchogenic carcinoma a long-term result comparable to that with radical lung resection. Angioplastic and combined broncho-angioplastic procedures should only be used in patients who cannot tolerate pneumonectomy due to poor cardiopulmonary reserve.
Topics: Bronchi; Carcinoma, Bronchogenic; Female; Humans; Lung Neoplasms; Male; Middle Aged; Pneumonectomy; Pulmonary Artery; Plastic Surgery Procedures; Survival Rate
PubMed: 15564159
DOI: 10.1016/S1015-9584(09)60031-2